Could not play the "Simon Bishop" role because of complications on another project, "Grosse Point Blank."

Griffith was considered for the role of Carol.

Holly Hunter turned down the lead in "As Good as it Gets" because she objected to the age difference between her character and Jack Nicholson.

Kline was attached to the film in early stages.

Upon the insistence of Jack Nicholson, author David Sedaris was asked to audition for the role that eventually went to Greg Kinnear. He turned it down, having no interest in playing a large movie role.

Uma Thurman was considered for the female lead, but the producers turned her down because she was too young.

John Travolta was considered for the role of Melvin.

Turned down the role of "Beverly" because, as animal rights activist, she objected to the way a dog is treated in the film.