Considered for the role of the young girl.

According to her autobiography, Patricia Neal said "no" to a major role because of personal problems in her life at the time.

Geraldine Page originated the role of Mother Miriam Ruth in the Broadway play by John Pielmeier, but was overlooked for the film.

The brilliant Amanda Plummer was passed over by director Norman Jewison for the part of Sister Agnes, although she had originated it on stage and was nominated for a Tony.