In a 2006 interview, Kal Penn (star of Harold and Kumar) said he auditioned for Tarantino but was unable to commit to the part because Grindhouse production conflicted with the filming of Epic Movie.

Ving Rhames turned the villainous role down before it was offered to Kurt Russell.

Mickey Rourke was originally cast to play "Stuntman Mike" in Grindhouse.

Sylvester Stallone said in Ain't it Cool News interview that hew was "hoping to work with Quentin in his new GRINDHOUSE film, but unfortunately ROCKY and RAMBO duties prevented that from happening."