David Arquette auditioned for the role of Billy, but decided he liked the role of Dewey more.

Barrymore was reportedly offered the lead role before accepting the part of Casey Becker instead.

Selma Blair auditioned for the role of Sidney, and was used in director Wes Craven's screen test. She also appears as Sarah Michelle Gellars friend (phone voice) in scream 2.

Melinda Clarke turned down a role in Scream supposedly because she had already done a horror movie a couple years before.

Was considered for the role of Sydney Prescott.

Garofalo turned down the part of Gail Weathers.

Scheduling conflicts prevented her from landing role of Tatum.

Auditioned for the role of Sydney Prescott in "Scream."

Freddie Prinze Jr. auditioned for the role of Stu.

Turned down the lead role because she didnt want to be playing a teen at 27.

Reese Witherspoon turned down a lead role.